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P450

P450

P450

P450

1

The present drug2013drug interaction can be attributed to a strong inhibitory effect on cytochrome P450-3A4 activity by voriconazole .

究其原因，是因为伏立康唑对细胞色素 P450-3A4 活性有强大的抑制作用。

2

The Cytochrome P450 superfamily participated in at least 16 key enzyme reactions in phenylpropanoid pathway .

细胞色素 P450 超家族参与苯丙烷途径的至少 16 种关键酶反应。

3

METHODS The ultraviolet spectrophotometric method was used to measure P450 concentration of hepatic microsomes .

方法紫外分光光度法测定大鼠肝微粒体 P450 含量；

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This review provides a better understanding of the cytochrome P450 system with a focus on those enzymes most involved in drug metabolism .

这次综述提供了一个对大多数药物代谢有关的酶为重点的细胞色素 P450 系统的了解。

6

Azole and triazole drugs are cytochrome P450 inhibitors widely used as fungal antibiotics and possessing potent antimycobacterial activity.

唑类和三氮唑类药物作为细胞色素 P450 抑制剂广泛被作为抗真菌药物和抗微生物药物使用。

8

OBJECTIVE To introduce the research status of cytochrome P450 and its new applications in clinical pharmacy .

目的介绍细胞色素 P450 的研究进展及其在临床药学工作实践中的指导意义。

10

An example of a flavoprotein undergoing a one-electron transfer is with the microsomal NADPH-cytochrome P450 reductase .

的一个经历一个单电子转移黄素蛋白的例子是与微粒 NADPH-细胞色素 P450 还原酶。

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Yeast does have endogenous microsomal cytochrome P450 enzymes and energy supporting systems, what is a major advantage for this host system .

酵母有内源性的微粒体和能量供给系统，这个系统对于宿主系统是个主要的有点。

13

OBJECTIVE To investigate the protective effects that phenobarbital sodium (Phe) induces cytochrome P450 (P450) against endotoxin (End ).

目的蜒究苯巴比妥钠诱导细胞色素 P450 （P450 ）对内毒素所致鼠毒性的保护作用。

14

Clopidogrel is metabolically activated by several hepatic cytochrome P450 (CYP) isoenzymes, including CYP1A2.

氯吡格雷通过肝脏细胞色素 P450 （CYP ）酶 ——包括 CYP1A2——代谢性激活。

15

Cytochrome P450 enzymes are very important for metabolism function in body .

细胞色素 P450 酶是体内代谢转换的重要酶系。

16

Furthermore, log P values for P450 substrates appear to represent markers for enzyme selectivity .

此外，记录 P 值为色素 P450 基板似乎代表标志酶选择性。

17

The progress on the relationship between cytochrome P450 and drug -induced liver injury was reviewed .

主要介绍细胞色素 P450 与药物性肝损伤的相关研究进展。

18

Conclusion The positive expression of aromatase P450 in cervical cancer tissues is related to the genesis of cervical carcinoma .

结论芳香化酶 P450 在宫颈癌组织的阳性表达可能参与宫颈癌的发生；

19

Cytochrome P450s are a large group of heme-binding enzymes and widely distribute in biology .

细胞色素 P450 是一种血红素结合蛋白，在生物界广泛存在。

20

Aim To investigate the influence of cytochrome P450 CYP2C9 polymorphism on the pharmacokinetics of tolbutamide.

目的研究细胞色素 P450CYP2C9 基因多态性对甲苯磺丁脲代谢动力学的影响。

21

The identified PLA1 gene encodes a cytochrome P450, CYP78A11, which potentially catalyzes substances controlling plant development .

PLA1 编码一个细胞色素 P450CYP78A11 ，可能催化控制叶片发育的底物。

22

The cloning strategies and identification methods of plant cytochrome P450s were summarized . And the future researches were predicted.

综述了植物细胞色素 P450 基因的克隆策略及鉴定方法，并对其未来研究作了展望。

23

Our results probably shed a light on studies of P450 genes in rice defense and development .

本研究对 P450 在水稻生长发育和防卫反应中的作用，以及 P450 基因簇的研究提供了基础。

24

Cytochrome P450 enzyme are an important enzyme family in drug metabolism .

细胞色素氧化酶 P450 是药物代谢中的一个重要的酶系。

25

P450 genes are widely involved in development and defense of plants .

植物 P450 广泛参与植物的生长发育以及防卫反应。

27

Here , lipophilicity is discussed with reference to the human drug-metabolizing P450 enzymes of families CYP1, CYP2 and CYP3.

在这里，脂溶性讨论参照人类药物代谢酶细胞色素 P450 的家庭 CYP1，CYP2 和 CYP3 。

28

ObjectiveTo introduce the effect of chemical constituents from Chinese herbal medicine on CYP3A4 isoform of cytochrome P450 system.

目的介绍中草药化学成分对细胞色素 P3A4 亚型影响。

29

Cytochrome P450 (CYP450) is the crucial metabolizing enzymes in the bodies . It is the most important effect for drug metabolization.

细胞色素 P450 （CYP450 ）是机体药物代谢的关键酶，在药物生物转化中起着重要作用。

30

In recent years, researches found that there were many kinds of cytochrome P450 enzymes which related to multidrug resistance of tumor .

目前的研究发现，有多类细胞色素 P450 酶与肿瘤多药耐药的发生密切相关。

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